By H. Seller, J. Czachurski, K. Dembowsky (auth.), Prof. Dr. W. Delius, Prof. Dr. E. Gerlach, Prof. Dr. H. Grobecker, Prof. Dr. W. Kübler (eds.)
An foreign Symposium "Catecholamines and the center" was once held in Munich in might 1981, which used to be prepared in cooperation with the Council on Cardiac Metabolism of the overseas Society and Federation of Cardiology and with the Microcirculation operating staff of the eu Society of Cardiology. It used to be the purpose of the organizers to guage during this Symposium the new advances made within the box of sympathetic keep an eye on of center functionality. specific consciousness was once given to neural sympathetic pathways, to mechanisms and results of adrenoceptor stimulation and blockade in addition to to clinically suitable implications in most cases concerning the value of catecholamines and of adrenoceptors in a number of middle illnesses. The wide scope used to be coated in 34 papers awarded by means of physiologists, pharmacologists and cardiologists in the course of a day assembly which used to be attended through a world viewers. This booklet comprises all papers in addition to the discussions following each one presentation. to complete speedy e-book the manuscripts are released as submitted through the authors. The discussions have been edited employing the written questions and solutions of the discussants. The Symposium used to be generously backed via Astra chemical substances GmbH, Wedell Holstein, Germany, which therefore made attainable a truly fruitful trade of data, principles and ideas among experts in a number of disciplines. The organizers gratefully recognize this help once more and wish to thank Dr. T. Kreuzer, the consultant of Astra chemical compounds, for his own engagement.
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Additional resources for Catecholamines and the Heart: Recent Advances in Experimental and Clinical Research
Br J PharmacoI52:549-577 19. Famebo LO, Hamberger B (1974) Influence of a- and f:l-adrenoceptors on the release of noradrenaline from field stimulated atria and cerebral cortex slices. J Pharm Pharmacol 26:644-646 20. Gillespie JS (1980) Presynaptic receptors in the autonomic nervous system. In: Szekeres L (ed) Handbook of Experimental Pharmacology, vol. 54/1. Springer, Berlin Heidelberg New York, pp 353-425 21. Graham RM, Stephenson WH, Pettinger WA (1980) Pharmacological evidence for a functional role of the prejunctional alpha-adrenoreceptor in noradrenergic neurotransmission in the conscious rat.
Crews FT, Smith CB (1978) Presynaptic alpha-receptor sub sensitivity after long-term antidepressant treatment. Science 202: 322-324 12. Dixon WR, Mosimann WF, Weiner N (1979) The role of presynaptic feedback mechanisms in regulation of norepinephrine release by nerve stimulation. J Pharmacol Exp Ther 209: 196-204 13. Docherty JR, McGrath JC (1979) An analysis of some factors influencing a-adrenoceptor feed-back at the sympathetic junction in the rat heart. Br J Pharmacol66: 55-63 14. Doxey JC (1977) Effect of clonidine on cardiac acceleration in pithed rats.
The investigators found two distinct groups of Kn's for each selective compound, thus indicating only two receptor subtypes. Similar results have been discussed by Nahorski . Although it is impossible to prove that there are only two subtypes, the available data strongly support this conclusion. The variation in apparent affinity constants for antagonists observed in different organs which has been taken as indicative of multiple f3-adrenoceptor subtypes can be explained on the basis of coexistence of f31 and f32 and variability in the relative density of the two types in the different organs.
Catecholamines and the Heart: Recent Advances in Experimental and Clinical Research by H. Seller, J. Czachurski, K. Dembowsky (auth.), Prof. Dr. W. Delius, Prof. Dr. E. Gerlach, Prof. Dr. H. Grobecker, Prof. Dr. W. Kübler (eds.)