Download e-book for iPad: Cancer Drug Resistance (Cancer Drug Discovery and by Beverly A. Teicher

By Beverly A. Teicher

ISBN-10: 1588295303

ISBN-13: 9781588295309

Best specialists summarize and synthesize the most recent discoveries about the alterations that happen in tumor cells as they enhance resistance to anticancer medicines, and recommend new techniques to fighting and overcoming it. The authors assessment physiological resistance dependent upon tumor structure, mobile resistance in response to drug delivery, epigenetic adjustments that neutralize or skip drug cytotoxicity, and genetic alterations that adjust drug aim molecules by means of reducing or disposing of drug binding and efficacy. Highlights contain new insights into resistance to antiangiogenic remedies, oncogenes and tumor suppressor genes in healing resistance, melanoma stem cells, and the improvement of better cures. There also are new findings on tumor immune break out mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

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Djonov VG, Kurz H, Burri PH. Optimality in the developing vascular system: branching remodeling by means of intussusception as an efficient adaptation mechanism. Dev Dyn 2002; 224:391–402. 52. Djonov V, Baum O, Burri PH. Vascular remodeling by intussusceptive angiogenesis. Cell Tissue Res 2003; 314:107–117. 53. Pries AR, Reglin B, Secomb TW. Structural response of microcirculatory networks to changes in demand: information transfer by shear stress. Am J Physiol 2003; 284:H2204–2212. 54. Dewhirst MW, Ong ET, Klitzman B, et al.

The Na+-coupled CI–/HCO3– exchange is also inhibited by depletion of ATP, and the Na+-independent Cl–/HCO3– exchange is inactivated by a low-pH environment (62,70). The relative importance in maintaining pHi at neutral range of the different mechanisms mentioned varies markedly in different cell types and under different conditions. The lactate /H+ symport, which is inhibited by the bioflavionoids quercetin and others, is one of the most active exchange in the regulation of pHi in tumor cells (71,72).

Science 2003; 302:1894; author reply 1894. 68. Rubin P, Casarett G. Microcirculation of tumors. II. The supervascularized state of irradiated regressing tumors. Clin Radiol 1966; 17:346–355. 69. Hilmas DE, Gillette EL. Tumor microvasculature following fractionated X-irradiation. Radiology 1975; 116:165–169. 70. Dewhirst MW, Oliver R, Tso CY, Gustafson C, Secomb T, Gross JF. Heterogeneity in tumor microvascular response to radiation. Int J Radiat Oncol Biol Phys 1990; 18:559–568. 71. Moeller BJ, Cao Y, Li CY, Dewhirst MW.

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Cancer Drug Resistance (Cancer Drug Discovery and Development) by Beverly A. Teicher


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