Androgen-Responsive Genes in Prostate Cancer: Regulation, - download pdf or read online

By Irina U. Agoulnik, Nancy L. Weigel (auth.), Zhou Wang (eds.)

ISBN-10: 1461461812

ISBN-13: 9781461461814

ISBN-10: 1461461820

ISBN-13: 9781461461821

Androgens and androgen receptors (AR) play severe roles within the improvement and development of prostate melanoma, the main often clinically determined melanoma and moment top reason for melanoma loss of life in US men. AR is an androgen-dependent DNA-binding transcription issue that regulates the expression of androgen-responsive genes. id and characterization of androgen-responsive genes offer insights into the mobile mechanisms of androgen motion and will bring about new methods in analysis, analysis, prevention and/or therapy of prostate melanoma. This quantity offers severe details from good revered specialists within the box. many of the interesting issues contain the recent figuring out of mechanisms underlining the law of androgen-responsive gene expression, and services of assorted androgen-responsive genes in organic procedures crucial in carcinogenesis together with telephone progress, angiogenesis, and epithelial-to-mesenchyme transition (EMT). different very important points addressed are the present and capability health center functions of data on androgen-responsive gene legislation and serve as. This e-book is meant for researchers, scientists, school, and complicated graduate scholars with an curiosity in androgen motion and prostate cancer.​

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Extra resources for Androgen-Responsive Genes in Prostate Cancer: Regulation, Function and Clinical Applications

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H. was supported by a grant of “The L’Oréal-Unesco Fellowship for Young Women in Science” and of the FWO. D. is holder of a Doctoral Fellowship of the FWO. B. is senior clinical investigator of the FWO and holder of the Leuven University Chair in Gerontology and Geriatrics. 2 Selective and Classical Androgen Response Elements in Androgen-Regulated... 25 References 1. Helsen C, Dubois V, Verfaillie A et al (2012) Evidence for DBD-LBD communications in the androgen receptor. Mol Cell Biol 32:3033–3043 2.

Verrijdt G, Schoenmakers E, Haelens A et al (2000) Change of specificity mutations in androgen-selective enhancers. Evidence for a role of differential DNA binding by the androgen receptor. J Biol Chem 275:12298–12305 32. Denayer S, Helsen C, Thorrez L et al (2010) The rules of DNA recognition by the androgen receptor. Mol Endocrinol 24:898–913 33. Umesono K, Evans RM (1989) Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell 57:1139–1146 34. Bolton EC, So AY, Chaivorapol C et al (2007) Cell- and gene-specific regulation of primary target genes by the androgen receptor.

Cato AC, Henderson D, Ponta H (1987) The hormone response element of the mouse mammary tumour virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region. EMBO J 6:363–368 3. Claessens F, Verrijdt G, Schoenmakers E et al (2001) Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation. J Steroid Biochem Mol Biol 76:23–30 4. Verrijdt G, Haelens A, Claessens F (2003) Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression.

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Androgen-Responsive Genes in Prostate Cancer: Regulation, Function and Clinical Applications by Irina U. Agoulnik, Nancy L. Weigel (auth.), Zhou Wang (eds.)


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