New PDF release: ANCA-Associated Vasculitides: Immunological and Clinical

By Richard A. DeRemee (auth.), Wolfgang L. Gross (eds.)

ISBN-10: 1475791828

ISBN-13: 9781475791822

ISBN-10: 1475791844

ISBN-13: 9781475791846

Preface: Pathophysiological Athophysiological elements and Antigen Specificity: cANCA-Targets. Proteinase three and so forth. pANCA-Targets: a. Myeloperoxidase. pANCA-Targets: b. different Lysosomal Antigens. ANCA-Targets: Endothelial cellphone components. Animal reports and Animal types. scientific features of Wegener's Granulomatosis and different ANCA linked illnesses: Wegener's and ANCA linked Vasculitis. healing techniques. ANCA and Inflamatory Bowel and Liver illnesses: Gastroenterologic features. a hundred articles. Index.

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Additional resources for ANCA-Associated Vasculitides: Immunological and Clinical Aspects

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Some of the released cationic cytoplasmic enzymes might, through charge-charge interactions, bind to the anionic heparan sulphate on the endothelial cell suface. neutrophils to cause further degranulation and release of damaging oxygen radicals (16). Alternatively, ANCA might bind to the endothelial cells through a proteinase 3 or myeloperoxidase bridge. It is interesting to note that we have shown this type of antigen bridging in SLE (DNA antibody-DNA-histone) (17) to be capable of up-regulation of adhesion molecules on endothelial cells in vitro (18).

Antibody-dependent cellular cytotoxicity of vascular endothelium: characterisation and pathogenic associations in systemic sclerosis, Clin. Exp. Immunol 78:358 (1989). 4. M. Leung, T Collins, LA. S. S Pober, Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma-interferon, J Clin. 77:1428 (1986). 43 5. M. L. L. Havens, M. S. Pober. Lytic antiendothelial cell antibodies in haemolytic-uraemic syndrome, Lancet. ii:183 (1988).

Moult, eta!. Antibody-dependent cellular cytotoxicity of vascular endothelium: characterisation and pathogenic associations in systemic sclerosis, Clin. Exp. Immunol 78:358 (1989). 4. M. Leung, T Collins, LA. S. S Pober, Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma-interferon, J Clin. 77:1428 (1986). 43 5. M. L. L. Havens, M. S. Pober. Lytic antiendothelial cell antibodies in haemolytic-uraemic syndrome, Lancet.

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ANCA-Associated Vasculitides: Immunological and Clinical Aspects by Richard A. DeRemee (auth.), Wolfgang L. Gross (eds.)


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