By Kai-Uwe Lewandrowski
Advances in Spinal Fusion finds a brand new iteration of fabrics and units for stronger operations in spinal fusion. This reference showcases rising study and applied sciences in parts akin to biodegradable implants, drug supply, stem telephone isolation and transfection, mobile encapsulation and immobilization, and the layout of 2nd and 3D scaffolds for cells. It captures a cascade of concepts an important to elevated therapeutic and diminished morbidity in spinal fusion tools and mechanics and addresses present criteria in analytical method and qc, it describes the choice of biomaterials for more desirable biocompatibility, biostability, and structure/function relationships.
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Additional info for Advances in Spinal Fusion: Molecular Science, BioMechanics, and Clinical Management
However, at least one ex vivo study suggests that temperature is not a mechanism of pain relief . In that study, temperature was measured at three locations (inside the anterior cortex, in the center of the VB, and in the spinal canal) after concurrent bipedicular injection of 10 mL of PMMA cement. Although temperatures exceeded 50ЊC for more than 1 minute at the center of the VB, the authors concluded that temperature was an unlikely mechanism of pain relief for several reasons. First, because the experiments were conducted on ex vivo VBs, the effect of active heat transfer due to blood profusion, as would be the case in vivo, was not included.
30. Leeson MC, Lippitt SB. Thermal aspects of the use of polymethylmethacrylate in large metaphyseal defects in bone. A clinical review and laboratory study. Clin. Orthop 1993; 295:239–245. 31. Mjoberg B, Pettersson H, Rosenqvist R, Rydholm A. Bone cement, thermal injury and the radiolucent zone. Acta Orthop. Scand 1984; 55:597–600. 32. Deramond H, Wright NT, Belkoff SM. Temperature elevation caused by bone cement polymerization during vertebroplasty. Bone 1999; 25:17S–21S. 33. Cotten A, Dewatre F, Cortet B, Assaker R, Leblond D, Duquesnoy B, Chastanet P, Clarisse J.
A. I. INTRODUCTION Spine care is trending towards procedures that are less invasive and motion sparing. Among the most innovative are kyphoplasty and vertebroplasty for the treatment of osteoporotic vertebral compression fractures (VCFs). They are performed percutaneously and focus on restoring the mechanical properties of the injured vertebra without fusing motion segments. These techniques have filled a void between prolonged nonoperative care and open surgical procedures by offering a highly effective treatment for pain relief with minimal risks to patients who otherwise would have few, if any, alternatives.
Advances in Spinal Fusion: Molecular Science, BioMechanics, and Clinical Management by Kai-Uwe Lewandrowski